Interview, Explained

In-depth breakdowns of tech interviews — section-by-section analysis with diagrams, quotes, and insights.

~59 min
a16z Podcast·

Steijn Pelle & Frédéric Renken on doing the job before you automate it

Steijn Pelle and Frédéric Renken· Co-founders of Lassie

The founders of Lassie explain how they built AI agents that autonomously run dental back-offices — by first doing the paperwork by hand, engineering for full autonomy over years, and reaching the Main Street businesses whose only 'incumbent' was a human who quit.

AgentsAI CompanyBusiness Strategy
~57 min
Startup School 2026·

Jeff Dean on why inference hardware is AI's next bottleneck

Jeff Dean· Chief Scientist of Google DeepMind and Google Research

At Y Combinator's Startup School 2026, Jeff Dean argues that as models commoditize the writing of code, the leverage moves down to the systems layer — specialized low-latency inference hardware and the energy cost of moving data — and up to the human skill of taste in choosing what to build.

AI InfrastructureInferenceAgentsTrainingLLM
~39 min
Y Combinator Startup School·

Sam Altman on why intelligence on tap raises the bar

Sam Altman· Co-founder and CEO of OpenAI

Altman argues AI agents compress startup execution from months to minutes, raising the ambition bar while making the concentration of power the central safety risk to design against.

AgentsAI CompanyBusiness StrategyAI Safety
~71 min
Latent Space·

Akshay Nathan on One Shared Harness, Two UX Shells

Akshay Nathan· Core Product Engineering lead at OpenAI

OpenAI merged Codex's agent power into ChatGPT Work behind one shared harness after non-developers quietly adopted the coding agent, betting that as AI blurs job roles the product should route users rather than box them in.

AgentsAI CompanyBusiness StrategyAI Infrastructure
~46 min
TWIML AI Podcast·

Damian Borth on Training Models From Models, Not Data

Damian Borth· Professor of AI and Machine Learning

St. Gallen's Damian Borth argues the weights of already-trained neural networks are a new data modality you can learn from and generate — letting you train new models from old models instead of scarce data, and one day sample a network on demand.

TrainingLLMAI InfrastructureOpen Source
~36 min
Startup School·

Boris Cherny on treating the model like a living creature

Boris Cherny· Creator of Claude Code

Boris Cherny, creator of Claude Code, argues that building on frontier models is an empirical craft: delete your scaffolding every generation, unhobble capability the product is hiding, and let the model verify its own work while it runs for days.

AgentsLLMAI SafetyReasoning
~49 min
Startup School 2026·

Jensen Huang on why learning is the greatest superpower

Jensen Huang· Founder and CEO of NVIDIA

At YC Startup School 2026, Jensen Huang argues that Nvidia's founding technology was flat wrong, that the durable edge across 34 years and $5 trillion was never any chip but the willingness to confront what he didn't know and learn it fast.

GPUAI InfrastructureRoboticsAgentsAI Company
~20 min
Startup School Paris·

Eric Landau on why physical AI is won at the data layer

Eric Landau· Co-founder and Co-CEO of Encord

Encord's Eric Landau explains why physical AI — roughly 80% of the economy — will be won not by cleverer models but by whoever can collect, curate, and evaluate multimodal data at petabyte scale.

RoboticsAI CompanyTrainingBusiness Strategy
~44 min
Lightcone·

Jay V on Why OpenCode Bets the Whole Field, Not One Model

Jay V· Founder and CEO of OpenCode

OpenCode's Jay V explains how a model-neutral, open-source coding agent reached ~13M users and ~7T tokens a day by betting the entire open-weight field and serving the world the frontier labs price out.

AgentsOpen SourceInferenceBusiness Strategy
~22 min
Y Combinator·

Matthieu Rouif & Eliot Andres on Why Ambition Is a Trainable Skill

Matthieu Rouif & Eliot Andres· Co-founders of PhotoRoom (CEO & CTO)

PhotoRoom's founders argue that ambition is not a personality trait but a skill you train: reset your benchmark against bolder peers, aim at targets so high they pull the company up to meet them, shrink every experiment to a V0 that AI can now ship in days, and earn scale by going deep on one thing at a time.

AI CompanyBusiness StrategyMultimodal
~14 min
Yahoo Finance·

Lisa Su on Why Inference Is AI's Real Inflection Point

Lisa Su· Chair and CEO of AMD

AMD's Lisa Su argues AI has crossed from training to inference — the everyday running of models — and that meeting accelerating demand will require abundant compute, open ecosystems, and capacity committed 12 to 24 months ahead.

AI InfrastructureInferenceAgentsBusiness Strategy
~42 min
Build Mode·

Sydney Sykes on why strategic fit wins partnerships

Sydney Sykes· Global VC Alliances and Partnerships lead at NVIDIA

Sydney Sykes, who runs Nvidia's VC alliances, breaks down how startups win corporate partnerships — by aligning to priorities, not by having the best tech — and how founders should build a cap table of realists and dreamers.

AI CompanyBusiness StrategyAI Infrastructure